{"id":6286,"date":"2025-06-10T21:36:46","date_gmt":"2025-06-10T12:36:46","guid":{"rendered":"https:\/\/cureverse.co.kr\/en\/?post_type=record&p=6286"},"modified":"2025-06-10T21:36:46","modified_gmt":"2025-06-10T12:36:46","slug":"%ed%81%90%ec%96%b4%eb%b2%84%ec%8a%a4-%ec%9e%90%ea%b0%80%eb%a9%b4%ec%97%ad-s1p1-%ec%9e%91%ec%9a%a9%ec%a0%9c-%e7%be%8e-1%ec%83%81-ind-%ec%8a%b9%ec%9d%b8","status":"publish","type":"record","link":"https:\/\/cureverse.co.kr\/en\/record\/%ed%81%90%ec%96%b4%eb%b2%84%ec%8a%a4-%ec%9e%90%ea%b0%80%eb%a9%b4%ec%97%ad-s1p1-%ec%9e%91%ec%9a%a9%ec%a0%9c-%e7%be%8e-1%ec%83%81-ind-%ec%8a%b9%ec%9d%b8\/","title":{"rendered":"\ud050\uc5b4\ubc84\uc2a4, \uc790\uac00\uba74\uc5ed \u2018S1P1 \uc791\uc6a9\uc81c\u2019 \u7f8e 1\uc0c1 \u201cIND \uc2b9\uc778\u201d"},"content":{"rendered":"

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\ud050\uc5b4\ubc84\uc2a4(Cureverse)\ub294 9\uc77c S1P1 \uc218\uc6a9\uccb4 \uc791\uc6a9\uc81c(agonist) \u2018CV-02\u2019\uc758 \uc784\uc0c11\uc0c1 \uc784\uc0c1\uc2dc\ud5d8\uacc4\ud68d\uc11c(IND)\ub97c \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA)\uc73c\ub85c\ubd80\ud130 \uc2b9\uc778\ubc1b\uc558\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

CV-02\ub294 S1P1(sphingosine-1-phosphate receptor 1)\uc5d0 \ud2b9\uc774\uc801\uc73c\ub85c \uc791\uc6a9\ud558\ub294 \uc800\ubd84\uc790\ud654\ud569\ubb3c\ub85c, \ub2e4\ubc1c\uc131\uacbd\ud654\uc99d(multiple sclerosis) \ub4f1\uc744 \uc801\uc751\uc99d\uc73c\ub85c \uc57d\ubb3c\uc744 \uac1c\ubc1c\ud558\uace0 \uc788\ub2e4. \ud050\uc5b4\ubc84\uc2a4\ub294 CV-02\uc758 \ube44\uc784\uc0c1\uc5d0\uc11c \uae30\uc874\uc758 S1P1 \ud0c0\uae43 \uc57d\ubb3c\ub300\ube44 \uc2ec\ud608\uad00 \ubd80\uc791\uc6a9\uc774 \ub0ae\uace0 \ub354 \ub192\uc740 \ud6a8\ub2a5\uc744 \ud655\uc778\ud588\ub2e4.<\/p>\n

\ud68c\uc0ac\ub294 CV-02\uc758 \uacbd\uc6b0 \uc2ec\ud608\uad00\ubd80\uc791\uc6a9 \uc704\ud5d8\uc744 \uc904\uc5ec \ub2e4\ubc1c\uc131\uacbd\ud654\uc99d \uc774\uc678\uc5d0 \ub2e4\ub978 \uc790\uac00\uba74\uc5ed\uc9c8\ud658\uc73c\ub85c \uc801\uc751\uc99d\uc744 \ud655\ub300\ud558\ub294\ub370 \uc720\ub9ac\ud560 \uac83\uc73c\ub85c \ubcf4\uace0 \uc788\ub2e4.<\/p>\n

\uc774\ubc88 \uc784\uc0c11\uc0c1\uc740 \uac74\uac15\ud55c \uc131\uc778 64\uba85\uc744 \ub300\uc0c1\uc73c\ub85c \uc9c4\ud589\ud55c\ub2e4. \ub2e8\uc77c\uc6a9\ub7c9\uc0c1\uc2b9\uc2dc\ud5d8(single ascending dose study, SAD)\uc5d0 40\uba85, \ub2e4\uc911\uc6a9\ub7c9\uc0c1\uc2b9\uc2dc\ud5d8(multiple ascending dose study, MAD)\uc5d0 24\uba85\uc744 \ubc30\uc815\ud574 \uc704\uc57d\uad70\uacfc \ube44\uad50\ud574 CV-02\uc758 \uc548\uc804\uc131, \ub0b4\uc57d\uc131 \ubc0f \uc57d\ub3d9\ud559\uc801 \ud2b9\uc131\uc744 \ud3c9\uac00\ud560 \uacc4\ud68d\uc774\ub2e4.<\/p>\n

\uc8fc\uc694 \uc548\uc804\uc131 \ud3c9\uac00 \uc9c0\ud45c\ub85c\ub294 \uc11c\ub9e5(bradycardia) \uc720\ubc1c\uc744 \ud655\uc778\ud558\uae30 \uc704\ud55c 24\uc2dc\uac04 \uc2ec\uc804\ub3c4(ECG) \uce21\uc815\uc744 \ud3ec\ud568\ud558\uba70, \uc545\ub825\ud559\uc801 \uc9c0\ud45c\ub85c\ub294 \uc808\ub300\ub9bc\ud504\uad6c\uc218(absolute lymphocyte count, ALC)\uc758 \uac10\uc18c\uc728\uc744 \uce21\uc815\ud55c\ub2e4.<\/p>\n

\ud2b9\ud788 \uc774\ubc88 IND \uc2b9\uc778\uc740 \uad6d\uac00\uc2e0\uc57d\uac1c\ubc1c\uc0ac\uc5c5\ub2e8(KDDF)\uc758 \ube44\uc784\uc0c1 \uc9c0\uc6d0\uacfc\uc81c\ub97c \ud1b5\ud574 \ube44\uc784\uc0c1 \uc5f0\uad6c\ub97c \uc644\ub8cc\ud588\uc73c\uba70, \uae00\ub85c\ubc8c RA(regulatory affairs) \uc9c0\uc6d0\uacfc\uc81c\ub97c \ud1b5\ud574 \uc804\ub7b5\uc801\uc774\uace0 \ud6a8\uc728\uc801\uc778 \ubbf8\uad6d FDA \uc2b9\uc778 \uc808\ucc28\ub97c \uc9c4\ud589\ud560 \uc218 \uc788\uc5c8\ub2e4\ub294 \uc810\uc5d0\uc11c \uc758\ubbf8\uac00 \ud06c\ub2e4\uace0 \ud68c\uc0ac\ub294 \uc124\uba85\ud588\ub2e4.<\/p>\n

\uc870\uc131\uc9c4 \ud050\uc5b4\ubc84\uc2a4 \ub300\ud45c\ub294 \u201c\ubbf8\uad6d \uc784\uc0c1\uc9c4\uc785\uc740 CV-02\uc758 \uae00\ub85c\ubc8c \uacbd\uc7c1\ub825\uacfc \uae30\uc220 \uc2e0\ub8b0\ub3c4\ub97c \ubcf4\uc774\ub294 \uc911\uc694\ud55c \uc774\uc815\ud45c\u201d\ub77c\uba70 \u201cCV-02\uc758 \uc6b0\uc218\ud55c \uc548\uc804\uc131\uacfc \uc720\ud6a8\uc131\uc744 \ubc14\ud0d5\uc73c\ub85c \uc18d\ub3c4\uac10 \uc788\ub294 \uac1c\ubc1c\uc5ed\ub7c9\uc744 \ubcf4\uc5ec\uc904 \uc218 \uc788\ub3c4\ub85d \ub178\ub825\ud558\uaca0\ub2e4\u201d\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\ud55c\ud3b8 \ud050\uc5b4\ubc84\uc2a4\ub294 \uc9c0\ub09c\ud574 10\uc6d4 \uc774\ud0c8\ub9ac\uc544 \uc81c\uc57d\uc0ac \uc548\uc824\ub9ac\ub2c8\ud30c\ub9c8(Angelini Pharma)\uc640 \ub9ac\ub4dc\uc5d0\uc14b\uc778 NRF2 \ud65c\uc131\uc81c \u2018CV-01\u2019\uc5d0 \ub300\ud574 3\uc5b57000\ub9cc\ub2ec\ub7ec(\uc57d 5000\uc5b5\uc6d0) \uaddc\ubaa8\uc758 \ub77c\uc774\uc120\uc2a4\uc544\uc6c3(L\/O) \uacc4\uc57d\uc744 \uccb4\uacb0\ud55c \ubc14 \uc788\ub2e4. \ub610\ud55c \uc11c\uc6b8\ubc14\uc774\uc624\ud5c8\ube0c\uc5d0\uc11c \uc9c4\ud589\ud558\ub294 \u20182025 \uc11c\uc6b8-\ubc14\uc824 \uc2a4\ud0c0\ud2b8\uc5c5 \ud5c8\ube0c \uc561\uc140\ub7ec\ub808\uc774\uc158 \ud504\ub85c\uadf8\ub7a8\u2019\uc5d0\ub3c4 \ucd5c\uc885 \uc120\uc815\ub418\uba70 \uae00\ub85c\ubc8c \uc0ac\uc5c5 \ud655\uc7a5\uc744 \uac00\uc18d\ud654\ud558\uace0 \uc788\ub2e4.<\/p>\n

\uc2e0\ucc3d\ubbfc \uae30\uc790 changmin.shin@bios.co.kr<\/p>\n","protected":false},"featured_media":6287,"parent":0,"template":"","meta":{"_acf_changed":false},"record-category":[19],"class_list":["post-6286","record","type-record","status-publish","has-post-thumbnail","hentry","record-category-main"],"acf":[],"_links":{"self":[{"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/record\/6286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/record"}],"about":[{"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/types\/record"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/media\/6287"}],"wp:attachment":[{"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/media?parent=6286"}],"wp:term":[{"taxonomy":"record-category","embeddable":true,"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/record-category?post=6286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}