{"id":5333,"date":"2024-12-10T00:00:00","date_gmt":"2024-12-09T15:00:00","guid":{"rendered":"https:\/\/cureverse.co.kr\/en\/record\/%ec%a1%b0%ec%84%b1%ec%a7%84-%ed%81%90%ec%96%b4%eb%b2%84%ec%8a%a4-%eb%8c%80%ed%91%9c-5000%ec%96%b5-%eb%b9%85%eb%94%9c-%eb%81%9d-%ec%95%84%eb%8b%8c-%ec%8b%9c%ec%9e%91\/"},"modified":"2025-05-31T22:47:40","modified_gmt":"2025-05-31T13:47:40","slug":"%ec%a1%b0%ec%84%b1%ec%a7%84-%ed%81%90%ec%96%b4%eb%b2%84%ec%8a%a4-%eb%8c%80%ed%91%9c-5000%ec%96%b5-%eb%b9%85%eb%94%9c-%eb%81%9d-%ec%95%84%eb%8b%8c-%ec%8b%9c%ec%9e%91","status":"publish","type":"record","link":"https:\/\/cureverse.co.kr\/en\/record\/%ec%a1%b0%ec%84%b1%ec%a7%84-%ed%81%90%ec%96%b4%eb%b2%84%ec%8a%a4-%eb%8c%80%ed%91%9c-5000%ec%96%b5-%eb%b9%85%eb%94%9c-%eb%81%9d-%ec%95%84%eb%8b%8c-%ec%8b%9c%ec%9e%91\/","title":{"rendered":"\uc870\uc131\uc9c4 \ud050\uc5b4\ubc84\uc2a4 \ub300\ud45c &#8220;5000\uc5b5 \ube45\ub51c, \ub05d \uc544\ub2cc \uc2dc\uc791"},"content":{"rendered":"<p>[\uc774\ub370\uc77c\ub9ac \uc11d\uc9c0\ud5cc \uae30\uc790] \u201c\uc548\uc804\uc131\uacfc \ud6a8\ub2a5\ub9cc \uc99d\uba85\ub410\ub2e4\uace0 \ubaa8\ub450 \ub2e4 \uc57d\uc774 \ub420 \uc218 \uc788\ub294 \uac74 \uc544\ub2d9\ub2c8\ub2e4. \uc57d\uc774 \ubab8 \uc548\uc5d0\uc11c \ud6a8\uacfc\ub97c \ub0b4\uace0 \uc798 \ubc30\ucd9c\ub418\ub294 \u2018\uc57d\ubb3c\uc131\u2019\ub3c4 \uc911\uc694\ud569\ub2c8\ub2e4. \uadf8\ub7f0 \uc810\uc5d0\uc11c \uc6b0\ub9ac \uc57d\ubb3c\uc740 3\ubc15\uc790\ub97c \ubaa8\ub450 \uac16\ucdc4\ub2e4\uace0 \uc0dd\uac01\ud569\ub2c8\ub2e4.\u201d<\/p>\n<figure id=\"attachment_5379\" aria-describedby=\"caption-attachment-5379\" style=\"width: 471px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-5379\" src=\"https:\/\/cureverse.co.kr\/en\/wp-content\/uploads\/2024\/12\/cv_news_12.jpg\" alt=\"\" width=\"471\" height=\"707\" srcset=\"https:\/\/cureverse.co.kr\/en\/wp-content\/uploads\/2024\/12\/cv_news_12.jpg 471w, https:\/\/cureverse.co.kr\/en\/wp-content\/uploads\/2024\/12\/cv_news_12-200x300.jpg 200w\" sizes=\"(max-width: 471px) 100vw, 471px\" \/><figcaption id=\"caption-attachment-5379\" class=\"wp-caption-text\">\uc870\uc131\uc9c4 \ud050\uc5b4\ubc84\uc2a4 \ub300\ud45c.(\uc81c\uacf5= \ud050\uc5b4\ubc84\uc2a4)<\/figcaption><\/figure>\n<p>\uc870\uc131\uc9c4 \ud050\uc5b4\ubc84\uc2a4 \ub300\ud45c\ub294 \uc9c0\ub09c 4\uc77c \uc774\ub370\uc77c\ub9ac\uc640 \ub9cc\ub098 \u201c\uc870(\u5146) \ub2e8\uc704 \uac00\uce58\ub97c \uc9c0\ub2cc \uc720\ub2c8\ucf58 \uae30\uc5c5\uc73c\ub85c \uc131\uc7a5\ud558\uaca0\ub2e4\u201d\uba70 \uc774\uac19\uc774 \ub9d0\ud588\ub2e4. \ud050\uc5b4\ubc84\uc2a4\ub294 \uc815\ubd80 \ucd9c\uc5f0 \uc5f0\uad6c \uae30\uad00 \uc911 \ud558\ub098\uc778 \ud55c\uad6d\uacfc\ud559\uae30\uc220\uc5f0\uad6c\uc6d0(KIST)\uc758 \uc5f0\uad6c\uc18c \uae30\uc5c5\uc774\ub2e4.<\/p>\n<p>\ud68c\uc0ac\ub294 \uc9c0\ub09c\ub2ec \uba39\ub294 \uc54c\uce20\ud558\uc774\uba38\ubcd1 \uce58\ub8cc\uc81c \ud6c4\ubcf4\ubb3c\uc9c8 \u2018CV-01\u2019\uc744 \uc784\uc0c1 1\uc0c1 \uc911 5000\uc5b5\uc6d0 \uaddc\ubaa8\ub85c \uae00\ub85c\ubc8c \uc81c\uc57d\uc0ac \uc548\uc824\ub9ac\ub2c8\ud30c\ub9c8\uc5d0 \uae30\uc220\uc774\uc804\ud588\ub2e4. \uc9c0\uae08\uae4c\uc9c0 \uacfc\ud559\uae30\uc220 \ubd84\uc57c \uc815\ubd80 \ucd9c\uc5f0 \uc5f0\uad6c \uae30\uad00\ub4e4\uc774 \uae30\ub85d\ud55c \uae30\uc220\uc774\uc804 \uacc4\uc57d \uaddc\ubaa8\ub85c\ub294 \uc5ed\ub300 \ucd5c\uace0\ub2e4. \uc5f0\uad6c \uc778\ub825\uc774 10\uba85 \ub0a8\uc9d3\ud55c \ucd08\uc18c\ud615 \ubc14\uc774\uc624\ubca4\ucc98\ub77c\ub294 \uc810\uc744 \uac10\uc548\ud558\uba74 \uc0c1\ub2f9\ud55c \uaddc\ubaa8\ub77c\ub294 \ud3c9\uac00\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<h6>\ucd08\uc18c\ud615 \ubca4\ucc98\uc758 \ucd08\ub300\ud615 \ube45\ub51c \ubc30\uacbd\uc740<\/h6>\n<p>\uc791\uc740 \ubc14\uc774\uc624\ubca4\ucc98\uac00 \uc774\ucc98\ub7fc \u2018\ube45\ub51c\u2019\uc744 \uc131\uc0ac\uc2dc\ud0ac \uc218 \uc788\ub358 \ubc30\uacbd\uc740 10\ub144\uc744 \uacf5\ub4e4\uc5ec \uac1c\ubc1c\ud55c \ud6c4\ubcf4\ubb3c\uc9c8 \uacbd\uc7c1\ub825\uc5d0\uc11c \ucc3e\uc544\ubcfc \uc218 \uc788\ub2e4.<\/p>\n<p>\ud68c\uc0ac\uc758 \uc8fc\ub825 \ud30c\uc774\ud504\ub77c\uc778\uc778 CV-01\uc740 \u2018\uc800\ubd84\uc790\u2019(Small molecule) \uacbd\uad6c\uc6a9 \uc57d\ubb3c\uc774\ub2e4. \ud2b9\uc815 \ud56d\uc6d0\uc5d0\ub9cc \ubc18\uc751\ud558\ub294 \ub2e8\ubc31\uc9c8 \uc131\ubd84\uc73c\ub85c \uad6c\uc131\ub41c \ud56d\uccb4 \uce58\ub8cc\uc81c\ubcf4\ub2e4 \ubd84\uc790 \ud06c\uae30\uac00 \ud6e8\uc52c \uc791\uc544 BBB(\ub1cc\ud608\uad00\uc7a5\ubcbd)\ub97c \ud1b5\uacfc\ud558\uae30 \uc6a9\uc774\ud558\ub2e4. \ubb34\uc5c7\ubcf4\ub2e4 \uc8fc\uc0ac\uc81c\ubcf4\ub2e4 \ubcf5\uc6a9 \ud3b8\uc758\uc131\uc774 \ub192\uc740 \uba39\ub294 \uc57d\uc774\ub77c\ub294 \uc810\ub3c4 \ucc28\ubcc4\uc810\uc774\ub2e4.<\/p>\n<p>CV-01\uc740 KEAP1 \ub2e8\ubc31\uc9c8\uc744 \uc120\ud0dd\uc801\uc73c\ub85c \ud0c0\uae43\ud574 NRF2\ub97c \ud65c\uc131\ud654\uc2dc\ucf1c \ub1cc \uc5fc\uc99d\uc744 \uc870\uc808\ud558\ub294 \uae30\uc804\uc744 \uac16\ub294\ub2e4. NRF2\ub294 \ubab8 \uc18d\uc5d0 \uc6d0\ub798 \uc788\ub294 \uc778\uc790\ub85c, \ub1cc \uc5fc\uc99d\uc744 \ud3ec\ud568\ud55c \ub9cc\uc131 \uc5fc\uc99d \uc870\uc808\uacfc \uc0b0\ud654\uc131 \uc2a4\ud2b8\ub808\uc2a4 \uc5b5\uc81c, \uc2e0\uacbd\uc138\ud3ec \ubcf4\ud638 \ub4f1 \uc5ed\ud560\uc744 \ud55c\ub2e4. \ubcf4\ud1b5 \uce58\ub9e4 \uc99d\uc0c1\uc740 \ub1cc\uc5d0 \uc5fc\uc99d\uc774 \ubc1c\uc0dd\ud558\uba74\uc11c \ub098\ud0c0\ub098\ub294 \uac83\uc774 \uc758\ud559\uc801\uc73c\ub85c \uc785\uc99d\ub41c \ub9cc\ud07c, NRF2\ub97c \ud65c\uc131\ud654\ud558\ub294 \uc57d\ubb3c\uc740 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc774\ub098 \ud30c\ud0a8\uc2a8\ubcd1 \uce58\ub8cc\uc81c\ub85c \uac1c\ubc1c\ub420 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uc54c\ub824\uc838 \uc788\ub2e4.<\/p>\n<p>\uc870 \ub300\ud45c\uc5d0 \ub530\ub974\uba74 \ucd5c\uadfc \uc2b9\uc778\ub41c \uc544\ubc00\ub85c\uc774\ub4dc \ubca0\ud0c0 \ud0c0\uae43 \uc54c\uce20\ud558\uc774\uba38\ubcd1 \uce58\ub8cc\uc81c\ub4e4\uc740 \ud658\uc790\ub4e4\uc5d0\uac8c \uce58\ub8cc \uc635\uc158\uc744 \uc81c\uacf5\ud55c\ub2e4\ub294 \uc810\uc5d0\uc11c \uc758\ubbf8\uc788\uc9c0\ub9cc, \uc544\uc9c1\uae4c\uc9c4 \uc5ec\ub7ec \ud55c\uacc4\uac00 \uc874\uc7ac\ud55c\ub2e4. \ub300\ud45c\uc801\uc73c\ub85c \uc544\ubc00\ub85c\uc774\ub4dc \uad00\ub828 \uc774\uc0c1 \uc99d\uc0c1(ARIA) \ubd80\uc791\uc6a9\uc774 \ub098\ud0c0\ub0a0 \uc218 \uc788\ub2e4\ub294 \uac83\uc774\ub2e4. \ub1cc\ubd80\uc885\uc774\ub098 \ub1cc \uc0bc\ucd9c, \ubbf8\uc138 \ucd9c\ud608 \ub4f1\uc774 \uc5ec\uae30\uc5d0 \ud574\ub2f9\ud55c\ub2e4. \ub610 \uc544\ubc00\ub85c\uc774\ub4dc \ubca0\ud0c0\ub97c \uc81c\uac70\ud55c\ub2e4\uace0 \ud574\uc11c \ud658\uc790\uc758 \uc778\uc9c0 \uae30\ub2a5\uc744 \uc644\uc804\ud788 \ubcf5\uad6c\ud558\uc9c0 \ubabb\ud55c\ub2e4\ub294 \uc810\ub3c4 \ud55c\uacc4\ub85c \uaf3d\ud78c\ub2e4.<\/p>\n<p>\uc870 \ub300\ud45c\ub294 \u201c\uc544\ubc00\ub85c\uc774\ub4dc \ubca0\ud0c0\uac00 \uc5c6\uc5b4\uc838\ub3c4 \uc778\uc9c0 \uae30\ub2a5\uc774 \uac1c\uc120\ub418\ub294 \ud6a8\uacfc\ub294 30%\uc5d0 \uadf8\uce58\uba70, \uadf8 \uc911\uc5d0\uc11c\ub3c4 30%\ub294 \ubd80\uc791\uc6a9 \uc774\uc288\uac00 \uc788\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc9c4\ub2e4\u201d\uba70 \u201c\uadf8\ub807\uae30 \ub54c\ubb38\uc5d0 \ucd5c\uadfc\uc5d0 \uadfc\uc6d0\uc801 \uce58\ub8cc\uc81c\uac00 \uac1c\ubc1c\ub3fc\uc57c \ud558\ub294 \uac83 \uc544\ub2c8\ub0d0\ub294 \uac8c \ud559\uacc4 \ud2b8\ub80c\ub4dc\ub2e4. \uc6b0\ub9ac \uc57d\ubb3c\uc740 \uc6b0\ub9ac \ubab8\uc744 \uc2a4\uc2a4\ub85c \ubcf4\ud638\ud558\ub294 \uae30\uc804\uc744 \ud65c\uc6a9\ud55c\ub2e4\ub294 \uc810\uc5d0\uc11c \uae30\uc874 \uc57d\ubb3c\ub4e4\uacfc \ucc28\ubcc4\ud654\ub41c\ub2e4\u201d\uace0 \ub9d0\ud588\ub2e4.<\/p>\n<p>CV-01\uc758 \uacbd\uc7c1\ub825\uc740 KEAP1 \ub0b4\uc5d0 \uc788\ub294 \uc544\ubbf8\ub178\uc0b0\uc778 \uc2dc\uc2a4\ud14c\uc778151(Cysteine151\u318dCys151)\uc5d0\ub9cc \uc120\ud0dd\uc801\uc73c\ub85c \ubc14\uc778\ub529\ud55c\ub2e4\ub294 \uac83\uc774\ub2e4. KEAP1\uc5d0\ub294 \uc2dc\uc2a4\ud14c\uc778151\uc678\uc5d0\ub3c4 \ub2e4\uc591\ud55c \ub2e8\ubc31\uc9c8\uc774 \uc788\ub294\ub370, \ub9cc\uc57d \uc57d\ubb3c\uc774 \ubab8 \uc548\uc5d0\uc11c \ub2e4\ub978 \ub2e8\ubc31\uc9c8\uacfc\ub3c4 \ubc18\uc751\ud560 \uacbd\uc6b0 \ub3c5\uc131 \ub2e8\ubc31\uc9c8\ub85c \ubcc0\ud560 \uac00\ub2a5\uc131\uc774 \ub192\ub2e4. \uc774\ub7f0 \uc810\uc5d0\uc11c \ud558\ub098\uc758 \ub2e8\ubc31\uc9c8\uacfc\ub9cc \uacf5\uc720 \uacb0\ud569\uc744 \ud558\ub294 \ud2b9\uc9d5\uc740 \uc57d\ubb3c \uc548\uc804\uc131\uc744 \ub192\uc77c \uc218 \uc788\ub2e4\ub294 \uac8c \ud68c\uc0ac \uce21 \uc124\uba85\uc774\ub2e4.<\/p>\n<p>CV-01\uc758 \ub610 \ub2e4\ub978 \uac15\uc810\uc740 \u2018\uc7a5\uae30\uc9c0\uc18d\u2019\uc774 \uac00\ub2a5\ud558\ub2e8 \uac83\uc774\ub2e4. \uc57d\ubb3c\uc774 \ubab8 \uc548\uc5d0\uc11c \uc5ec\ub7ec \uac1c\uc758 C151\uacfc \ubd99\uace0, \ub5a8\uc5b4\uc9c0\uace0\ub97c \ubc18\ubcf5\ud574 NFR2\ub97c \uacc4\uc18d\ud574\uc11c \ud65c\uc131\ud654 \uc2dc\ud0a4\ub294 \uc774\ub978\ubc14 \u2018\uac00\uc5ed\uc801 \uacf5\uc720\uacb0\ud569\u2019\uc744 \ud55c\ub2e4. \uc774 \ub54c\ubb38\uc5d0 \ubab8 \uc548\uc5d0\uc11c \uc624\ub79c \uae30\uac04 \ud6a8\ub2a5\uc744 \uc9c0\uc18d\ud560 \uc218 \uc788\ub2e4\ub294 \uc124\uba85\uc774\ub2e4.<\/p>\n<p>\uc870 \ub300\ud45c\ub294 \u201c\ud604\uc874\ud558\ub294 KEAP1-NRF2 \ud0c0\uae43 \uc57d\ubb3c\ub4e4\uc758 \uacbd\uc6b0, KEAP1\uc758 \uc2dc\uc2a4\ud14c\uc778151 \uc678 \ub2e4\ub978 \uc2dc\uc2a4\ud14c\uc778\uc5d0\ub3c4 \ubd99\ub294\ub2e4\ub294 \ud55c\uacc4\uac00 \uc788\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc9c4\ub2e4. \uc774\ub7f0 \ud2b9\uc9d5\uc740 \uc57d\ud6a8\ub97c \ub5a8\uc5b4\ub728\ub9ac\uac70\ub098 \ubd80\uc791\uc6a9\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\ub2e4\u201d\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n<p>CV-01\uc740 \uc54c\uce20\ud558\uc774\uba38\ubcd1 \uc608\ubc29 \uac00\ub2a5\uc131\ub3c4 \uc788\ub2e4. \ud68c\uc0ac\ub294 \uc774\uc640 \uad00\ub828\ud574 CV-01 \ucd08\uae30 \ud22c\uc5ec\uc2dc, \uc544\ubc00\ub85c\uc774\ub4dc \ubca0\ud0c0 \uc0dd\uc131\uc744 \uc5b5\uc81c\ud558\ub294 \ud6a8\ub2a5\uc744 \ub3d9\ubb3c\uc2dc\ud5d8\uc5d0\uc11c \ud655\uc778\ud588\ub2e4.<\/p>\n<p>\uc870 \ub300\ud45c\ub294 \u201c\uc6b0\ub9ac \uc57d\ubb3c\uc740 \uce58\ub9e4 \uace0\uc704\ud5d8\uad70 \ud658\uc790\uc5d0\uac8c \uce58\ub9e4 \ud310\uc815\uc744 \ubc1b\uae30 \uc804\ubd80\ud130 \uc608\ubc29\uc6a9\uc73c\ub85c \ubcf5\uc6a9\ud558\ub3c4\ub85d \ud558\ub294 \uac83\ub3c4 \uac00\ub2a5\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ud558\ub2e4\u201d\uba70 \u201c\ub9c8\uc6b0\uc2a4\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc2e4\ud5d8\uc5d0\uc11c \ucd5c\ub300 10\uac1c\uc6d4 \uac00\ub7c9 \uc77c\ucc0d \uc57d\ubb3c\uc744 \ud22c\uc5ec\ud588\ub354\ub2c8 \uc2e4\uc81c \uce58\ub9e4\uac00 \uac78\ub9ac\ub294 \uae30\uac04\uc744 \ub354 \ub2a6\ucd94\ub294 \uac83\uc744 \ud655\uc778\ud588\ub2e4\u201d\uace0 \ubc1d\ud614\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<h6>\u201c3\ub144 \ub0b4 \uae30\uc5c5\uacf5\uac1c \ucd94\uc9c4\u201d<\/h6>\n<p>\ud050\uc5b4\ubc84\uc2a4\ub294 \ub610 \ub2e4\ub978 \ub300\uaddc\ubaa8 \uae30\uc220\uc774\uc804\uc744 \ub51c\uc744 \uae30\ub300\ud558\uace0 \uc788\ub2e4. \ub450 \ubc88\uc9f8 \ud30c\uc774\ud504\ub77c\uc778\uc778 \u2018CV-02\u2019\ub294 \ub2e4\ubc1c\uc131 \uacbd\ud654\uc99d \uce58\ub8cc\uc81c\ub97c \ubaa9\ud45c\ub85c \uac1c\ubc1c\uc774 \uc9c4\ud589 \uc911\uc774\uba70, \ub0b4\ub144 \ucd08 \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA)\uc5d0 \uc784\uc0c1 1\uc0c1 \uc2e0\uccad\uc744 \ud560 \uacc4\ud68d\uc774\ub2e4.<\/p>\n<p>CV-02\ub294 \uae30\uc874 \uce58\ub8cc\uc81c\ub4e4\uacfc \ub9c8\ucc2c\uac00\uc9c0\ub85c \ud608\uc561 \ub0b4 \uba74\uc5ed\uc138\ud3ec \uc774\ub3d9\uc744 \uc870\uc808\ud558\ub294 \u2018S1P1\u2019 \ub2e8\ubc31\uc9c8\uc744 \ud0c0\uae43\ud55c\ub2e4. \ud050\uc5b4\ubc84\uc2a4\ub294 \uc0ac\ub78c \uc2ec\uc7a5 \uc870\uc9c1\uc744 \uc774\uc6a9\ud55c \uc2ec\uc7a5\uacc4 \ubd80\uc791\uc6a9 \uadf9\ubcf5 \uc2dc\ud5d8 \uacb0\uacfc, \ub2e4\uad6d\uc801 \ud68c\uc0ac\uc758 \uacbd\uc7c1 \uc57d\ubb3c \ub300\ube44 \ubd80\uc791\uc6a9\uc774 100\ubd84\uc758 1 \uc218\uc900\uc784\uc744 \ud655\uc778\ud588\ub2e4\ub294 \uc124\uba85\uc774\ub2e4.<\/p>\n<p>\uc870 \ub300\ud45c\ub294 \u201c\uc774\ub974\uba74 3\ub144 \uc548\uc5d0 \uae30\uc5c5\uc0c1\uc7a5(IPO)\uc5d0\ub3c4 \ub3c4\uc804\ud560 \uac83\u201d\uc774\ub77c\uba70 \u201c\ube45\ud30c\ub9c8 \uc57d\ubb3c\ubcf4\ub2e4 10\ubc30 \uc815\ub3c4 \uc548\uc804\ud558\uace0 \ub354 \ud6a8\ub2a5\uc774 \uc88b\uc740 \uae00\ub85c\ubc8c \ubca0\uc2a4\ud2b8-\uc778-\ud074\ub798\uc2a4(\uacc4\uc5f4 \ub0b4 \ucd5c\uace0 \uc57d\ubb3c)\uc744 \ubaa9\ud45c\ub85c \ud55c\ub2e4\u201d\uace0 \ub9d0\ud588\ub2e4.<\/p>\n<p>\ud050\uc5b4\ubc84\uc2a4\ub294 \ud604\uc7ac \uc2dc\ub9ac\uc988B \ud22c\uc790 \uc720\uce58\ub97c \uc9c4\ud589 \uc911\uc774\uba70, \uc774\ub2ec \uc911 \ub51c\uc774 \ud074\ub85c\uc9d5\ub420 \uc804\ub9dd\uc774\ub2e4. \ud22c\uc790 \uc720\uce58\uac00 \uc608\uc815\ub418\ub85c \ub9c8\ubb34\ub9ac \ub41c\ub2e4\uba74 \ud050\uc5b4\ubc84\uc2a4\uc758 \ub204\uc801 \ud22c\uc790\uae08\uc740 \uc57d 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