{"id":5322,"date":"2025-04-04T00:00:00","date_gmt":"2025-04-03T15:00:00","guid":{"rendered":"https:\/\/cureverse.co.kr\/en\/record\/%ec%a0%95%eb%b6%80%ea%b0%80-%eb%bd%91%ec%9d%80-%ec%b4%88%ea%b2%a9%ec%b0%a8-%ec%8b%a0%ec%95%bd%ea%b8%b0%ec%97%85-%ed%81%90%ec%96%b4%eb%b2%84%ec%8a%a4-%ec%a0%80%eb%b6%84%ec%9e%90-%ec%84%a4%ea%b3%84\/"},"modified":"2025-05-31T21:46:00","modified_gmt":"2025-05-31T12:46:00","slug":"%ec%a0%95%eb%b6%80%ea%b0%80-%eb%bd%91%ec%9d%80-%ec%b4%88%ea%b2%a9%ec%b0%a8-%ec%8b%a0%ec%95%bd%ea%b8%b0%ec%97%85-%ed%81%90%ec%96%b4%eb%b2%84%ec%8a%a4-%ec%a0%80%eb%b6%84%ec%9e%90-%ec%84%a4%ea%b3%84","status":"publish","type":"record","link":"https:\/\/cureverse.co.kr\/en\/record\/%ec%a0%95%eb%b6%80%ea%b0%80-%eb%bd%91%ec%9d%80-%ec%b4%88%ea%b2%a9%ec%b0%a8-%ec%8b%a0%ec%95%bd%ea%b8%b0%ec%97%85-%ed%81%90%ec%96%b4%eb%b2%84%ec%8a%a4-%ec%a0%80%eb%b6%84%ec%9e%90-%ec%84%a4%ea%b3%84\/","title":{"rendered":"\uc815\ubd80\uac00 \ubf51\uc740 \ucd08\uaca9\ucc28 \uc2e0\uc57d\uae30\uc5c5 ‘\ud050\uc5b4\ubc84\uc2a4’, \uc800\ubd84\uc790 \uc124\uacc4\ub85c \uc2b9\ubd80\uc218"},"content":{"rendered":"

\uae00\ub85c\ubc8c \ub1cc\uc9c8\ud658 \uce58\ub8cc \uc2dc\uc7a5\uc740 \uace0\ub839\ud654\uc640 \ub9de\ubb3c\ub824 \ube60\ub974\uac8c \uc131\uc7a5\ud558\uace0 \uc788\ub2e4. \ud558\uc9c0\ub9cc \uc2e0\uc57d \ud6c4\ubcf4\ubb3c\uc9c8\uc744 \ud655\ubcf4\ud558\uace0\ub3c4 BBB(\ud608\ub1cc\uc7a5\ubcbd) \ud1b5\uacfc, \uc548\uc804\uc131, \ub3c5\uc131 \ubb38\uc81c\uc5d0 \ub9c9\ud600 \uac1c\ubc1c\uc744 \ud3ec\uae30\ud558\ub294 \uae30\uc5c5\uc774 \uc801\uc9c0 \uc54a\ub2e4. \uc774 \uac00\uc6b4\ub370 \ud050\uc5b4\ubc84\uc2a4\ub294 \uc57d\ubb3c \uc124\uacc4 \ub2e8\uacc4\ubd80\ud130 \uace0\ud488\uc9c8 \uc57d\ubb3c\uc131\uc744 \uace0\ub824\ud55c \uc800\ubd84\uc790 \uc2e0\uc57d\uc744 \uc9c1\uc811 \uc124\uacc4\ud558\uace0, \ucd5c\uc801\ud654\ud558\uba70, \uc804\uc784\uc0c1\uae4c\uc9c0 \uac80\uc99d \uac00\ub2a5\ud55c \uc5ed\ub7c9\uc744 \ub0b4\uc138\uc6cc \ucd5c\uadfc ‘\ucd08\uaca9\ucc28 \ucc3d\uc5c5\uae30\uc5c5 1000+ \ud504\ub85c\uc81d\ud2b8 (DIPS)’\uc5d0 \uc774\ub984\uc744 \ub2f9\ub2f9\ud788 \uc62c\ub838\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

\ud050\uc5b4\ubc84\uc2a4\ub294 \uae30\uc804 \uc774\ud574\ubd80\ud130 \ud0c0\uae43 \uc120\uc815, \ubb3c\uc9c8 \ubc1c\uad74\uacfc \ucd5c\uc801\ud654, \ube44\uc784\uc0c1 \uc5f0\uad6c, \uc784\uc0c1 1\uc0c1 \uc9c4\uc785\uae4c\uc9c0 \uc804 \uacfc\uc815\uc744 \ucc3d\uc5c5 3\ub144 \ub9cc\uc5d0 \uc644\uc131\ud588\uc73c\uba70, \uadf8 \uacb0\uacfc\ubb3c\uc778 ‘CV-01’\uc740 \uc774\ud0c8\ub9ac\uc544 \uc548\uc824\ub9ac\ub2c8\ud30c\ub9c8\uc5d0 \uc57d 5000\uc5b5\uc6d0 \uaddc\ubaa8\ub85c \uae30\uc220\uc774\uc804(L\/O)\ub410\ub2e4. <\ud788\ud2b8\ub274\uc2a4>\uc640 \ub9cc\ub09c \uc870\uc131\uc9c4 \ub300\ud45c\ub294 “\uc57d\ubb3c\uc774 \ub420 \ub9cc\ud55c \uace0\ud488\uc9c8\uc758 \uad6c\uc870\ub97c \ucc98\uc74c\ubd80\ud130 \uc124\uacc4\ud558\uace0, \uc6b0\ub9ac\uac00 \uac00\uc9c4 \ub77c\uc774\ube0c\ub7ec\ub9ac\uc5d0\uc11c \ubc14\ub85c \ud6c4\ubcf4\ubb3c\uc9c8\uc744 \ub3c4\ucd9c\ud574\ub0bc \uc218 \uc788\ub294 \uac8c \uac15\uc810\uc774\ub2e4. \uc57d\uc774 \ub420 \uc218 \uc788\ub294 \uac00\ub2a5\uc131\ubd80\ud130 \ub2e4\ub974\ub2e4”\uace0 \uac15\uc870\ud588\ub2e4.<\/p>\n

\"\"
\uc870\uc131\uc9c4 \ud050\uc5b4\ubc84\uc2a4 \ub300\ud45c<\/figcaption><\/figure>\n

 <\/p>\n

\uc800\ubd84\uc790 \uc2e0\uc57d \uac1c\ubc1c, \ud050\uc5b4\ubc84\uc2a4\uac00 \uace0\uc9d1\ud558\ub294 \uc774\uc720<\/strong><\/p>\n

\ud050\uc5b4\ubc84\uc2a4\ub294 \uc800\ubd84\uc790(small molecule) \uae30\ubc18 \uc2e0\uc57d \uac1c\ubc1c\uc744 \uc804\ubb38\uc73c\ub85c \ud55c\ub2e4. \ud56d\uccb4, \ub2e8\ubc31\uc9c8, RNA \ub4f1 \ubc14\uc774\uc624\uc758\uc57d\ud488\uc774 \uac01\uad11\ubc1b\ub294 \uc2dc\ub300\uc9c0\ub9cc, \ud050\uc5b4\ubc84\uc2a4\ub294 \uc624\ud788\ub824 \uac00\uc7a5 \uc804\ud1b5\uc801\uc778 \ubc29\uc2dd\uc758 \uc2e0\uc57d \uc124\uacc4\ub85c\ubd80\ud130 \ub2f5\uc744 \ucc3e\ub294\ub2e4. \uadf8 \uc120\ud0dd\uc5d0\ub294 \uacfc\ud559\uc801 \uadfc\uac70\uc640 \uacbd\ud5d8, \uadf8\ub9ac\uace0 \ud655\uace0\ud55c \uc804\ub7b5\uc774 \uc788\ub2e4.<\/p>\n

\uc870\uc131\uc9c4 \ub300\ud45c\ub294 “\uc6b0\ub9ac\uac00 \uac00\uc7a5 \uc798\ud560 \uc218 \uc788\ub294 \uc601\uc5ed\uc774\uae30 \ub54c\ubb38”\uc774\ub77c\uace0 \ub2e8\uc5b8\ud55c\ub2e4. \uadf8\ub294 “\uae30\uc220\uc774\ub77c\ub294 \uac74 \ud2b8\ub80c\ub4dc\ub97c \uc887\ub294 \uac83\uc774 \uc544\ub2c8\ub77c, \uc6b0\ub9ac\uac00 \uc798\ud560 \uc218 \uc788\ub294 \uac83\uc744 \ubc14\ud0d5\uc73c\ub85c \ud655\uc2e4\ud55c \uacb0\uacfc\ub97c \ub0b4\ub294 \uac83\uc774 \ud2b9\ud788 \ucd08\uae30 \uc2a4\ud0c0\ud2b8\uc5c5\uc740 \uc911\uc694\ud558\ub2e4. \uc800\ubd84\uc790\ub294 \uc6b0\ub9ac\uac00 \uc9c1\uc811 \uad6c\uc870\ub97c \uc124\uacc4\ud558\uace0, \ucd5c\uc801\ud654\ud558\uace0, \ube60\ub974\uac8c \uc804\uc784\uc0c1\uc73c\ub85c \uac00\uc838\uac08 \uc218 \uc788\ub294 \ud50c\ub7ab\ud3fc\uc744 \uac00\uc9c0\uace0 \uc788\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\uc800\ubd84\uc790 \uc2e0\uc57d\uc740 \ubb3c\uc9c8 \uc124\uacc4\uac00 \ud575\uc2ec\uc774\ub2e4. \ub300\ud615 \ubd84\uc790\uc640 \ub2ec\ub9ac \uc791\uace0 \ub2e8\uc21c\ud55c \uad6c\uc870 \uc18d\uc5d0\uc11c \uc120\ud0dd\uc131\uacfc \ud6a8\ub2a5, \uc548\uc804\uc131, \uc57d\ubb3c\ub3d9\ud0dc\ud559\uae4c\uc9c0 \ubaa8\ub450 \ud655\ubcf4\ud574\uc57c \ud55c\ub2e4. \uc870 \ub300\ud45c\ub294 “\uc800\ubd84\uc790 \uc57d\ubb3c\uc740 \uae30\ubcf8\uc801\uc73c\ub85c \ubb3c\uc9c8 \ucd5c\uc801\ud654\uc640 \uc57d\ubb3c\uc124\uacc4\uc758 \uc815\uad50\ud568\uc774 \uc694\uad6c\ub41c\ub2e4. \uc6b0\ub9ac\uac00 \ub9cc\ub4e0 \uace0\uc720\uc758 \ub77c\uc774\ube0c\ub7ec\ub9ac\uc5d0\uc11c \ucd08\uae30 \ud65c\uc131 \ud654\ud569\ubb3c(hit)\uc744 \ubc1c\uad74\ud558\uace0, ADME(\ud761\uc218\u00b7\ubd84\ud3ec\u00b7\ub300\uc0ac\u00b7\ubc30\uc124)\uc640 Tox(\ub3c5\uc131)\ub97c \uace0\ub824\ud574 \ube60\ub974\uac8c \uc120\ub3c4 \ud654\ud569\ubb3c(lead)\uc744 \ub3c4\ucd9c\ud560 \uc218 \uc788\ub294 \ub178\ud558\uc6b0\uac00 \uc788\ub2e4”\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n

\ud050\uc5b4\ubc84\uc2a4\ub294 \uc790\uccb4\uc801\uc73c\ub85c \ub77c\uc774\ube0c\ub7ec\ub9ac\ub97c \uc124\uacc4\ud558\uace0 \ubcf4\uc720\ud558\uace0 \uc788\ub2e4. \ub2e8\uc21c\ud788 \uc0c1\uc6a9\ud654\ub41c \ud654\ud569\ubb3c \ub77c\uc774\ube0c\ub7ec\ub9ac\ub97c \ub3c4\uc785\ud574 \uc0ac\uc6a9\ud558\ub294 \ubc29\uc2dd\uc774 \uc544\ub2c8\ub2e4. \uadf8\ub294 “\ub0a8\ub4e4\uc774 \ub2e4 \uac19\uc774 \uc4f8 \uc218 \uc788\ub294 \ub77c\uc774\ube0c\ub7ec\ub9ac\ub294 \uc758\ubbf8\uac00 \uc5c6\ub2e4. \uc6b0\ub9ac\ub9cc\uc758 \ub3c5\ucc3d\uc131\uc744 \uac16\ucdb0\uc57c \ud55c\ub2e4. \uc608\ub97c \ub4e4\uc5b4 \ub1cc\uc9c8\ud658 \ud0c0\uae43\uc774\uba74 BBB\ub97c \uc798 \ud1b5\uacfc\ud560 \uc218 \uc788\ub294 \ubb3c\uc131\uc744 \uac16\ucd98 \ub77c\uc774\ube0c\ub7ec\ub9ac\uac00 \ud544\uc694\ud558\uace0, \uc804\uc2e0\uc5d0 \uc791\uc6a9\ud574\uc57c \ud558\ub294 \uc57d\ubb3c\uc774\ub77c\uba74 \uae30\ubcf8\uc801\uc778 \uc57d\ubb3c\uc131\uc774 \uc6b0\uc218\ud574\uc57c \ud55c\ub2e4. \uc6b0\ub9ac\ub294 \uc774\ub7f0 \uae30\uc900\uc5d0 \ub9de\ucdb0 \ub77c\uc774\ube0c\ub7ec\ub9ac\ub97c \uc9c1\uc811 \ub9cc\ub4e4\uc5b4\uac00\uace0 \uc788\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac\ub294 \uc9c8\uc801\uc73c\ub85c \uace0\ub3c4\ud654\ub41c \uc124\uacc4 \uae30\ubc18\uc5d0\uc11c \uc791\ub3d9\ud55c\ub2e4. \uadf8\ub294 “\ub2e8\uc21c\ud788 \ub77c\uc774\ube0c\ub7ec\ub9ac \uac1c\uc218\ub098 \ud654\ud569\ubb3c \uc218\ub97c \ub9d0\ud558\ub294 \uac8c \uc544\ub2c8\ub2e4. \uc5bc\ub9c8\ub098 \uc57d\uc774 \ub420 \uc218 \uc788\ub294 \uad6c\uc870\ub97c \uac00\uc9c0\uace0 \uc788\ub290\ub0d0\uac00 \uc911\uc694\ud558\ub2e4. \uc6b0\ub9ac\ub294 li-structure, \uc989 ‘likelihood-to-be-a-drug structure’\ub97c \uae30\uc900\uc73c\ub85c \ub77c\uc774\ube0c\ub7ec\ub9ac\ub97c \uc124\uacc4\ud558\uace0 \uc788\uc73c\uba70, \uc57d\uc774 \ub420 \uac00\ub2a5\uc131\uc774 \ub192\uc740 \uace0\ud488\uc9c8 \ud654\ud569\ubb3c\uc744 \uc911\uc2ec\uc73c\ub85c \uad6c\uc131\ud558\uace0 \uc788\ub2e4”\uace0 \uac15\uc870\ud588\ub2e4.<\/p>\n

\uc57d\ubb3c\uc758 \uad6c\uc870\ub97c \uc5b4\ub5bb\uac8c \ub9cc\ub4dc\ub290\ub0d0\ub294 \ud050\uc5b4\ubc84\uc2a4\uac00 \uac00\uc9c4 \uac00\uc7a5 \ub3c5\ubcf4\uc801\uc778 \ucca0\ud559\uc774\ub2e4. \uc870 \ub300\ud45c\ub294 “\uc800\ud76c\ub294 \uc57d\ubb3c \ub514\uc790\uc778\uc744 \uc9c1\uc811 \ud55c\ub2e4. \ucef4\ud4e8\ud130 \uae30\ubc18 \uc124\uacc4\ub3c4 \ubcd1\ud589\ud558\uc9c0\ub9cc, \uae30\ubcf8\uc740 \uc0ac\ub78c\uc774 \uc190\uc73c\ub85c \uad6c\uc870\ub97c \uadf8\ub9ac\uace0 \uc0dd\uac01\ud558\uba70 \ub9cc\ub4e4\uc5b4\ub0b8\ub2e4. \uc218\ubc31 \uac1c \uad6c\uc870\ub97c \uc885\uc774\uc5d0 \uadf8\ub824\ubcf4\uace0, \uc5b4\ub5a4 \uad6c\uc870\uac00 \ub354 \uc57d\ubb3c\uc131, \uc120\ud0dd\uc131, \ub3c5\uc131 \uce21\uba74\uc5d0\uc11c \uc6b0\uc218\ud55c \uc9c0\ub97c \ud310\ub2e8\ud55c\ub2e4. \uadf8\uac8c \uc9c4\uc9dc \uc57d\uc744 \ub9cc\ub4dc\ub294 \ubc29\uc2dd\uc774\ub77c\uace0 \ubbff\ub294\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\uc774\ub7ec\ud55c \uad6c\uc870 \uae30\ubc18 \uc124\uacc4\ub825\uc740 \ub2e8\uc21c\ud788 \uc544\uc774\ub514\uc5b4\ub97c \ud604\uc2e4\ub85c \uad6c\ud604\ud558\ub294 \ub370 \uadf8\uce58\uc9c0 \uc54a\ub294\ub2e4. \uc57d\ubb3c\uc758 ‘\uc57d\ubb3c\ub85c\uc11c\uc758 \uc801\ud569\uc131(druggability)’\uc744 \ub192\uc774\uace0, \uc2dc\uc7a5\uc5d0 \ub3c4\ub2ec\ud560 \ud655\ub960\uc744 \ub192\uc774\ub294 \ud575\uc2ec \uc5ed\ub7c9\uc774\ub2e4. \uc2e4\uc81c\ub85c \ud050\uc5b4\ubc84\uc2a4\uc758 \uc57d\ubb3c\uc740 \ucd08\uae30 \uad6c\uc870 \uc124\uacc4 \ub2e8\uacc4\uc5d0\uc11c\ubd80\ud130 BBB \ud22c\uacfc\uc131, \uc6a9\ud574\ub3c4, \ub300\uc0ac \uc548\uc815\uc131, \uc624\ud504\ud0c0\uae43 \ub3c5\uc131, \ub3cc\uc5f0\ubcc0\uc774 \uc720\ubc1c \uac00\ub2a5\uc131\uae4c\uc9c0 \uace0\ub824\ub3fc \uc788\ub2e4.<\/p>\n

\uadf8\ub294 “\uc57d\uc740 \ubab8 \uc548\uc5d0\uc11c \uc791\uc6a9\ud574\uc57c \ud558\uae30 \ub54c\ubb38\uc5d0 ADME\uc640 Tox\uac00 \ucd08\uae30\ubd80\ud130 \uc548\uc815\ub3fc \uc788\uc5b4\uc57c \ud55c\ub2e4. \uc6b0\ub9ac\ub294 \uc124\uacc4\ub2e8\uacc4\uc5d0\uc11c\ubd80\ud130 \uc774\ub7f0 \uae30\uc900\uc744 \ubc18\uc601\ud574\uc11c \ud6a8\ub2a5 \ud655\uc778 \uc774\uc804\uc5d0\ub3c4 \uc57d\ubb3c\uc131\uc740 \uc774\ubbf8 \uc6b0\uc218\ud55c \uc0c1\ud0dc\ub2e4. \uadf8 \uacb0\uacfc lead \ucd5c\uc801\ud654 \uc18d\ub3c4\ub3c4 \ube60\ub974\uace0, \ud6c4\ubcf4\ubb3c\uc9c8 \ud655\uc815 \uc774\ud6c4 \uc784\uc0c1 \uc9c4\uc785\uae4c\uc9c0\uc758 \uc804\ud658\uc728\ub3c4 \ub192\ub2e4”\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n

 <\/p>\n

CV-01, Keap1\/Nrf2 \uacbd\ub85c \uc870\uc808\ud558\ub294 \uc54c\uce20\ud558\uc774\uba38 \uce58\ub8cc\uc81c\uc758 \ub4f1\uc7a5<\/strong><\/p>\n

\ud050\uc5b4\ubc84\uc2a4\uc758 \ub300\ud45c \ud30c\uc774\ud504\ub77c\uc778 CV-01\uc740 Keap1-Nrf2 \uc0c1\ud638\uc791\uc6a9\uc744 \uc870\uc808\ud558\ub294 \ud601\uc2e0 \uae30\uc804\uc758 \uc800\ubd84\uc790 \uc2e0\uc57d\uc774\ub2e4. \ucd5c\uadfc \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74, \uc54c\uce20\ud558\uc774\uba38 \ud658\uc790\uc5d0\uc11c\ub294 Nrf2 \ud65c\uc131\uc774 \uc815\uc0c1 \ub178\ud654\uad70\uc5d0 \ube44\ud574 \ud604\uc800\ud788 \uac10\uc18c\ud574 \uc788\uc73c\uba70, \uc774\ub85c \uc778\ud574 \uc5fc\uc99d \uc5b5\uc81c \ubc0f \ud56d\uc0b0\ud654 \ubc18\uc751\uc774 \uc57d\ud654\ub3fc \uc2e0\uacbd\uc138\ud3ec \uc190\uc0c1\uc774 \ucd09\uc9c4\ub41c\ub2e4. \ud050\uc5b4\ubc84\uc2a4\ub294 \uc774 \ubcd1\ud0dc\uc0dd\ub9ac\ub97c \uc815\uba74\uc73c\ub85c \uaca8\ub0e5\ud574 \uc0c8\ub85c\uc6b4 \uce58\ub8cc \uc804\ub7b5\uc744 \uc138\uc6e0\ub2e4.<\/p>\n

CV-01\uc740 Keap1 \ub2e8\ubc31\uc9c8\uc758 \uc2dc\uc2a4\ud14c\uc778 151\ubc88\uc744 \uc120\ud0dd\uc801\uc73c\ub85c \ud654\ud559\uc801\uc73c\ub85c \ubcc0\ud615\ud574, Nrf2\uc758 \uc720\ube44\ud034\ud2f4\ud654\ub97c \uc5b5\uc81c\ud558\uace0 \uc774\ub97c \ud575 \ub0b4\ub85c \uc774\ub3d9\uc2dc\ud0a8\ub2e4. \uc774\ub85c \uc778\ud574 HO-1, NQO1, GCLM, GCLC \ub4f1 \ud56d\uc0b0\ud654 \ubc0f \ud56d\uc5fc\uc99d \uc720\uc804\uc790\ub4e4\uc758 \ubc1c\ud604\uc774 \ucd09\uc9c4\ub418\uba70, \uc2e0\uacbd\uc138\ud3ec \ubcf4\ud638 \ud6a8\uacfc\uac00 \uc720\ub3c4\ub41c\ub2e4. \uc870\uc131\uc9c4 \ub300\ud45c\ub294 “\uae30\uc874\uc758 Nrf2 \ud65c\uc131\ud654 \ubb3c\uc9c8\uc740 \ub300\ubd80\ubd84 \ube44\uc120\ud0dd\uc801\uc774\uace0, \ucc9c\uc5f0\ubb3c \uae30\ubc18\uc774\ub77c \uc57d\ubb3c\uc131\uacfc \uc120\ud0dd\uc131\uc774 \ub5a8\uc5b4\uc9c4\ub2e4. \ubc18\uba74, CV-01\uc740 Keap1\uc758 \ud2b9\uc815 \uc2dc\uc2a4\ud14c\uc778 \uc794\uae30\ub97c \uc120\ud0dd\uc801\uc73c\ub85c \ud654\ud559\uc801\uc73c\ub85c \ubcc0\ud615\ud558\ub3c4\ub85d \uc124\uacc4\ub41c \uad6c\uc870\ub2e4”\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n

\uc791\uc6a9\uae30\uc804\uc758 \uc815\ud655\uc131\uc744 \uc785\uc99d\ud558\uae30 \uc704\ud574, \ud050\uc5b4\ubc84\uc2a4\ub294 \uc57c\uc0dd\ud615(WT) Keap1\ubfd0 \uc544\ub2c8\ub77c \uc138 \uac00\uc9c0 \ubcc0\uc774\uccb4(mutant Keap1) \ub2e8\ubc31\uc9c8\uc744 \uc815\uc81c\ud574 \ube44\uad50 \uc2e4\ud5d8\uc744 \uc9c4\ud589\ud588\ub2e4. \uc774 \uacfc\uc815\uc5d0\uc11c CV-01\uc774 151\ubc88 \uc2dc\uc2a4\ud14c\uc778\uc5d0\ub9cc \ud2b9\uc774\uc801\uc73c\ub85c \uc791\uc6a9\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ud655\uc778\ub410\ub2e4. \uc870 \ub300\ud45c\ub294 “\uad6c\uc870\uae30\ubc18 \uc124\uacc4\ub97c \ud1b5\ud574 \uc6d0\ud558\ub294 \ud45c\uc801\uc5d0\ub9cc \uc791\uc6a9\ud558\uac8c\ub054 \ubd84\uc790\ub97c \uc124\uacc4\ud588\uae30 \ub54c\ubb38\uc5d0 \uac00\ub2a5\ud588\ub2e4”\uace0 \uac15\uc870\ud588\ub2e4.<\/p>\n

\uc804\uc784\uc0c1\uc5d0\uc11c\ub294 \ud6a8\ub2a5\ubfd0 \uc544\ub2c8\ub77c \uc548\uc804\uc131 \uce21\uba74\uc5d0\uc11c\ub3c4 \ub9e4\uc6b0 \uc6b0\uc218\ud55c \uacb0\uacfc\ub97c \uc5bb\uc5c8\ub2e4. CV-01\uc740 APP\/PS1 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c \ud22c\uc5ec \uc2dc \uc544\ubc00\ub85c\uc774\ub4dc \ud50c\ub77c\ud06c \ud615\uc131\uc744 \uc5b5\uc81c\ud558\uace0, \uc778\uc9c0\uae30\ub2a5\uc744 \uc720\uc758\ubbf8\ud558\uac8c \uac1c\uc120\ud588\ub2e4. \ud2b9\ud788 \uc218\uc911\ubbf8\ub85c \uc2e4\ud5d8(Morris water maze)\uc5d0\uc11c \ud22c\uc5ec\uad70\uc758 \ud559\uc2b5\u00b7\uae30\uc5b5 \ub2a5\ub825\uc774 \ud604\uc800\ud788 \ud5a5\uc0c1\ub410\uc73c\uba70, \ub1cc \uc5fc\uc99d \ubc18\uc751 \uc5ed\uc2dc \uc870\uc9c1\ud559\uc801\uc73c\ub85c \uac10\uc18c\ud558\ub294 \uac83\uc774 \ud655\uc778\ub410\ub2e4. \uc870 \ub300\ud45c\ub294 “KIST \ub1cc\uacfc\ud559\uc5f0\uad6c\uc18c\uc5d0\uc11c \ub2e4\uc591\ud55c \uc57d\ubb3c\uc744 \ud14c\uc2a4\ud2b8\ud588\ub294\ub370, CV-01\ub9cc\ud07c \ub69c\ub837\ud55c \uc778\uc9c0\uac1c\uc120 \ud6a8\uacfc\ub97c \ubcf4\uc778 \uc57d\uc740 \ub4dc\ubb3c\uc5c8\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\uc57d\ubb3c\uc131 \ud504\ub85c\ud30c\uc77c\ub3c4 \ub3c5\ubcf4\uc801\uc774\ub2e4. CV-01\uc740 \ub0ae\uc740 hERG \uc800\ud574\ub3c4(IC\u2085\u2080 = 112 \u03bcM), \ub0ae\uc740 CYP \uc800\ud574, \uc591\ud638\ud55c \uc6a9\ud574\ub3c4 \ubc0f \ub300\uc0ac\uc548\uc815\uc131, favorable PK(\uc57d\ub3d9\ud559)\ub97c \ubaa8\ub450 \uac16\ucdc4\ub2e4. \uc870 \ub300\ud45c\ub294 “\uc6b0\ub9ac\ub294 \ud6c4\ubcf4\ubb3c\uc9c8 \ub2e8\uacc4\ubd80\ud130 ADME\uc640 \ub3c5\uc131\uc744 \uac80\ud1a0\ud574 \uc57d\ubb3c\uc131\uc744 \ucda9\ubd84\ud788 \ud655\ubcf4\ud55c \uad6c\uc870\ub9cc\uc744 \ubc1c\uc804\uc2dc\ud0a8\ub2e4. CV-01\uc740 \ud6a8\ub2a5 \uc774\uc804\uc5d0 \uc774\ubbf8 \uc57d\ubb3c\ub85c\uc11c\uc758 \uc644\uc131\ub3c4\ub97c \uac16\ucd98 \uc0c1\ud0dc\uc600\ub2e4”\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n

\ub610\ud55c \uc774 \uc57d\ubb3c\uc740 \uc608\ubc29\uc57d\uc73c\ub85c\uc11c\uc758 \uac00\ub2a5\uc131\ub3c4 \ubcf4\uc5ec\uc92c\ub2e4. 3\uac1c\uc6d4, 5\uac1c\uc6d4 \uc2dc\uc810\uc758 \uc870\uae30 \ud22c\uc5ec\ub97c \ud1b5\ud574 \uc544\ubc00\ub85c\uc774\ub4dc \ud50c\ub77c\ud06c\uc758 \uc0dd\uc131\uc774 \ub2a6\ucdb0\uc9c0\uace0, \uc778\uc9c0 \uae30\ub2a5\ub3c4 \ub354 \ub69c\ub837\ud558\uac8c \uac1c\uc120\ub410\ub2e4\ub294 \uacb0\uacfc\uac00 \ub098\uc654\ub2e4. “\ucd08\uae30\ubd80\ud130 \uba39\uc774\uba74 \uce58\ub9e4 \ubc1c\ubcd1\uc744 \uc9c0\uc5f0\uc2dc\ud0a4\uac70\ub098 \uc644\ud654\ud560 \uc218 \uc788\ub2e4\ub294 \uac00\ub2a5\uc131\uc774 \ubcf4\uc600\ub2e4. \uc548\uc804\uc131\ub3c4 \ub192\uace0 \uacbd\uad6c \uce58\ub8cc\uc81c\uc774\uae30\ub54c\ubb38\uc5d0 \uc608\ubc29\uc57d\uc73c\ub85c\ub3c4 \ucda9\ubd84\ud788 \uace0\ub824\ud560 \uc218 \uc788\ub2e4”\uace0 \uac15\uc870\ud588\ub2e4.<\/p>\n

\ud604\uc7ac CV-01\uc740 \ud55c\uad6d\uc5d0\uc11c \uc784\uc0c1 1\uc0c1\uc744 \uc9c4\ud589 \uc911\uc774\ub2e4. 2023\ub144 6\uc6d4 \uc11c\uc6b8\ub300\ubcd1\uc6d0\uc5d0\uc11c IND \uc2b9\uc778\uc744 \ubc1b\uc558\uc73c\uba70, \uac74\uac15\ud55c \uc131\uc778\uacfc \ucf54\uce74\uc2dc\uc548 \ud3ec\ud568 \uad6c\uc870\ub85c \uc124\uacc4\ub410\ub2e4. \uc870 \ub300\ud45c\ub294 “\ucf54\uce74\uc2dc\uc548\uc744 \ud3ec\ud568\ud55c \uc774\uc720\ub294 \uae00\ub85c\ubc8c \uc9c4\ucd9c\uc744 \uc5fc\ub450\uc5d0 \ub480\uae30 \ub54c\ubb38\uc774\ub2e4. \uc62c\ud574 \uc548\uc5d0 \uc784\uc0c1 1\uc0c1 \uc644\ub8cc \ubc0f \uacb0\uacfc \ubc1c\ud45c\uac00 \uac00\ub2a5\ud560 \uac83\uc73c\ub85c \ubcf8\ub2e4”\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

 <\/p>\n

CV-02, \uc2ec\uc7a5 \ub3c5\uc131\uc744 \uadf9\ubcf5\ud55c \ud3b8\ud5a5 \uc791\uc6a9\uc81c, \uc790\uac00\uba74\uc5ed\uc9c8\ud658\uc758 \uc0c8 \ub300\uc548<\/strong><\/p>\n

\ud050\uc5b4\ubc84\uc2a4\uc758 \ub450 \ubc88\uc9f8 \ud575\uc2ec \ud30c\uc774\ud504\ub77c\uc778 CV-02\ub294 S1P1 \uc218\uc6a9\uccb4\ub97c \ud0c0\uae43\uc73c\ub85c \ud558\ub294 \uc790\uac00\uba74\uc5ed\uc9c8\ud658 \uce58\ub8cc\uc81c\ub2e4. \uc774 \uacc4\uc5f4\uc740 \ub2e4\ubc1c\uc131\uacbd\ud654\uc99d(MS), \uc5fc\uc99d\uc131\uc7a5\uc9c8\ud658(IBD), \uc544\ud1a0\ud53c\ud53c\ubd80\uc5fc \ub4f1 \ub2e4\uc591\ud55c \uc790\uac00\uba74\uc5ed\uc9c8\ud658\uc5d0\uc11c \ud6a8\uacfc\uc801\uc778 \ud0c0\uae43\uc73c\ub85c \ud3c9\uac00\ubc1b\uace0 \uc788\uc9c0\ub9cc, \uae30\uc874 \uc57d\ubb3c\ub4e4\uc740 \uc2ec\ubc15\uc218 \uc800\ud558(\uc11c\ub9e5), \uc2ec\uc804\ub3c4 \uc774\uc0c1 \ub4f1 \uc2ec\uc7a5 \ubd80\uc791\uc6a9\uc73c\ub85c \uc778\ud574 \uc801\uc751\uc99d \ud655\uc7a5\uc5d0 \uc81c\ud55c\uc774 \ub9ce\uc558\ub2e4. \ud050\uc5b4\ubc84\uc2a4\ub294 \uc774\ub7ec\ud55c \ud55c\uacc4\ub97c \uc791\uc6a9\uae30\uc804 \uc790\uccb4\uc5d0\uc11c\ubd80\ud130 \ud574\uacb0\ud558\ub294 \uc804\ub7b5\uc744 \ucc44\ud0dd\ud588\ub2e4.<\/p>\n

CV-02\ub294 \uae30\uc874 \uc57d\ubb3c\uacfc \ub2ec\ub9ac \ud3b8\ud5a5\uc131 \uc791\uc6a9\uc81c(biased agonist) \uc804\ub7b5\uc744 \uae30\ubc18\uc73c\ub85c \uc124\uacc4\ub410\ub2e4. \uc870\uc131\uc9c4 \ub300\ud45c\ub294 “CV-02\ub294 G\ub2e8\ubc31\uc9c8(G-protein) \uacbd\ub85c\ub294 \ucc28\ub2e8\ud558\uace0, \u03b2-arrestin \uacbd\ub85c\ub9cc\uc744 \ud3b8\ud5a5\uc801\uc73c\ub85c \ud65c\uc131\ud654\ud558\ub294 \uad6c\uc870\ub2e4. \uc2ec\uc7a5 \ubd80\uc791\uc6a9\uc744 \uc77c\uc73c\ud0a4\ub294 \uc2e0\ud638\ub294 \ud53c\ud558\uace0, \uba74\uc5ed\uc138\ud3ec \uc774\ub3d9 \uc5b5\uc81c\ub77c\ub294 \ud575\uc2ec \ud6a8\ub2a5\uc740 \uc720\uc9c0\ud558\ub294 \ubc29\uc2dd\uc774\ub2e4”\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n

\uc774 \uac19\uc740 \uc804\ub7b5\uc740 \uc57d\ubb3c \uc124\uacc4 \ub2e8\uacc4\uc5d0\uc11c\ubd80\ud130 \ubd84\uc790\uc801 \ud2b9\uc131\uc744 \ubc18\uc601\ud574 \ub9cc\ub4e4\uc5b4\uc84c\ub2e4. \uadf8\ub294 “G-protein \uae30\ubc18 \uc2e0\ud638\uc804\ub2ec\uc744 \uc77c\uc73c\ud0a4\ub294 \uae30\uc874 S1P1 \uc791\uc6a9\uc81c\ub4e4\uc740 \uc218\uc6a9\uccb4\uc758 \ube44\ud2b9\uc774\uc801 \ud65c\uc131\ud654\ub97c \uc720\ub3c4\ud574 \uc2ec\uc7a5 \uc804\ub3c4\uacc4\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce5c\ub2e4. \uc6b0\ub9ac\ub294 \uc218\uc6a9\uccb4 \uad6c\uc870\uc758 \uacb0\ud569 \ud3ec\uc778\ud2b8\ub97c \ubd84\uc11d\ud574 \u03b2-arrestin \uacbd\ub85c\ub9cc\uc744 \ud65c\uc131\ud654\ud558\ub3c4\ub85d \uad6c\uc870\ub97c \uc870\uc815\ud588\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\uc2e4\uc81c\ub85c CV-02\ub294 \uae30\uc804 \uc120\ud0dd\uc131\uacfc \ud6a8\ub2a5\uc5d0\uc11c \ubaa8\ub450 \uc6b0\uc218\ud55c \uacb0\uacfc\ub97c \ud655\ubcf4\ud588\ub2e4. \ub300\ud45c\uc801\uc778 \ub3d9\ubb3c\ubaa8\ub378\uc778 EAE(mouse model of MS) \uc2e4\ud5d8\uc5d0\uc11c\ub294 \uae30\uc874 \uc57d\ubb3c \ub300\ube44 10\ubc30 \uc774\uc0c1 \uac15\ub825\ud55c \uce58\ub8cc \ud6a8\uacfc\ub97c \ubcf4\uc600\uace0, \uc5fc\uc99d\uc131 \uc9c8\ud658 \uc9c0\ud45c\ub3c4 \uc720\uc758\ud558\uac8c \uac1c\uc120\ub410\ub2e4. \uc870 \ub300\ud45c\ub294 “\uc5fc\uc99d \uc5b5\uc81c \ud6a8\uacfc\ubfd0 \uc544\ub2c8\ub77c \uc7ac\ubc1c \ube48\ub3c4\uc640 \uc9c8\ubcd1 \uc9c4\ud589 \uc9c0\uc5f0 \ud6a8\uacfc\uae4c\uc9c0 \ud655\uc778\ud560 \uc218 \uc788\uc5c8\ub2e4. \uae30\uc874 \uce58\ub8cc\uc81c\ubcf4\ub2e4 \ud6e8\uc52c \uc548\uc815\uc801\uc778 \uba74\uc5ed \uc870\uc808 \uae30\uc804\uc744 \ud655\ubcf4\ud588\ub2e4\uace0 \ud310\ub2e8\ud55c\ub2e4”\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n

\ub610\ud55c, in vitro \uc2dc\ud5d8\uc5d0\uc11c\ub3c4 CV-02\uc758 \ubc14\uc774\uc5b4\uc2a4 \uc791\uc6a9 \uae30\uc804\uc774 \uc218\uce58\ub85c \uc785\uc99d\ub410\ub2e4. \uacbd\uc7c1\uc57d\ubb3c\uacfc \ube44\uad50\ud574 \u03b2-arrestin \uc120\ud0dd\uc131\uc740 10\ubc30 \uc774\uc0c1 \ub192\uc558\uace0, G-protein \ud65c\uc131\ub3c4\ub294 \uc5b5\uc81c\ub41c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4. “\uc774 \ub370\uc774\ud130\ub294 CV-02\uac00 \uc2e4\uc81c \uc138\ud3ec \uc218\uc900\uc5d0\uc11c \uc791\uc6a9\uae30\uc804 \uc0c1\uc758 \ucc28\ubcc4\uc131\uc744 \ud655\ubcf4\ud558\uace0 \uc788\ub2e4\ub294 \uc99d\uac70\ub2e4. \ubc14\uc774\uc5b4\uc2a4 \uc57d\ubb3c \uc124\uacc4\uc758 \uc131\uacf5 \uac00\ub2a5\uc131\uc744 \uad6c\uccb4\uc801\uc73c\ub85c \ubcf4\uc5ec\uc900 \uc0ac\ub840\ub77c \ud560 \uc218 \uc788\ub2e4”\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n

\ub3c5\uc131 \uce21\uba74\uc5d0\uc11c\ub3c4 \ud050\uc5b4\ubc84\uc2a4\ub294 \ucca0\uc800\ud55c \ube44\uad50\uc2e4\ud5d8\uc744 \uc9c4\ud589\ud588\ub2e4. \uae00\ub85c\ubc8c CRO\uc778 \uc544\ub098\uc2a4\ubc14\uc774\uc624(Anabios)\uc640 \ud611\ub825\uc744 \ud1b5\ud574 \uc0ac\ub78c \uc2ec\uc7a5 \uc870\uc9c1 \uae30\ubc18(human cardiac tissue) \ud50c\ub7ab\ud3fc\uc5d0\uc11c \uc57d\ubb3c\uc758 \uc804\uae30\uc801 \uc2e0\ud638 \ubcc0\ud654\ub97c \ud3c9\uac00\ud588\uace0, \uae30\uc874 \uc57d\ubb3c \ub300\ube44 CV-02\ub294 QT \uc5f0\uc7a5 \ubc0f \ub9ac\ub4ec \ubcc0\ud654 \uac00\ub2a5\uc131\uc774 \ud604\uc800\ud788 \ub0ae\uc558\ub2e4. \uc870 \ub300\ud45c\ub294 “\uc2ec\uc7a5 \ub3c5\uc131\uc774 \uc774 \uacc4\uc5f4 \uc57d\ubb3c\uc5d0\uc11c \uac00\uc7a5 \ud070 \ub9ac\uc2a4\ud06c\uc778\ub370, CV-02\ub294 \uc0ac\ub78c \uc870\uc9c1 \uae30\ubc18 \ubaa8\ub378\uc5d0\uc11c\ub3c4 \uc774 \ub9ac\uc2a4\ud06c\ub97c \ud68c\ud53c\ud560 \uc218 \uc788\ub2e4\ub294 \uac83\uc744 \ubcf4\uc5ec\uc92c\ub2e4”\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n

CV-02\ub294 \ud604\uc7ac FDA IND \uc81c\ucd9c\uc744 \uc900\ube44 \uc911\uc774\ub2e4. \uc804\uc784\uc0c1 \ub3c5\uc131\uc2dc\ud5d8\uc740 \ub9c8\ubb34\ub9ac \ub2e8\uacc4\uc5d0 \uc788\uc73c\uba70, \uc62c\ud574 \ud558\ubc18\uae30 \ubbf8\uad6d\uc5d0\uc11c \uc784\uc0c1 1\uc0c1\uc5d0 \uc9c4\uc785\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud55c\ub2e4. \ub2e4\ubc1c\uc131\uacbd\ud654\uc99d\uc744 1\ucc28 \uc801\uc751\uc99d\uc73c\ub85c \uc124\uc815\ud588\uc73c\uba70, \ud5a5\ud6c4 \uc5fc\uc99d\uc131\uc7a5\uc9c8\ud658, \uc544\ud1a0\ud53c\ud53c\ubd80\uc5fc \ub4f1\uc73c\ub85c \uc801\uc751\uc99d\uc744 \ud655\ub300\ud560 \uacc4\ud68d\uc774\ub2e4. \uc870 \ub300\ud45c\ub294 “CV-02\ub294 \uc57d\ubb3c \uc124\uacc4 \ub2e8\uacc4\ubd80\ud130 \uc548\uc804\uc131\uacfc \uc120\ud0dd\uc131\uc744 \ubaa8\ub450 \ud655\ubcf4\ud55c \uc57d\ubb3c\uc774\ub2e4. \ud55c\uacc4\uac00 \ub69c\ub837\ud588\ub358 \uae30\uc874 \uacc4\uc5f4\uc5d0\uc11c \uc0c8\ub85c\uc6b4 \uae30\ud68c\ub97c \ub9cc\ub4e4 \uc218 \uc788\ub2e4\uace0 \ubcf8\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

 <\/p>\n

\uc124\uacc4\ubd80\ud130 \uc0c1\uc5c5\ud654\uae4c\uc9c0 \uc900\ube44\ub3fc \uc788\uc5b4<\/strong><\/p>\n

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\uadf8\ub294 \uc774\uc5b4 “\ud22c\uc790\uc790\ub4e4\uc774 \uc6b0\ub9ac\ub97c \uc88b\uac8c \ubcf8 \uac74 \ub2e8\uc21c\ud788 \ub51c \ub54c\ubb38\uc774 \uc544\ub2c8\uc5c8\ub2e4. \uace0\ud488\uc9c8\uc758 \uc800\ubd84\uc790 \ud6c4\ubcf4\ubb3c\uc9c8\uc744 \ubc18\ubcf5\ud574\uc11c \ubc1c\uad74\ud558\uace0 \ucd5c\uc801\ud654\ud560 \uc218 \uc788\ub2e4\ub294 \uc810, \uc989 \uc124\uacc4\uc758 \uc7ac\ud604\uc131\uacfc \uc77c\uad00\uc131\uc744 \uc2e0\ub8b0\ud55c \uac83\uc774\ub2e4”\uace0 \uac15\uc870\ud588\ub2e4.<\/p>\n

\uad81\uadf9\uc801\uc73c\ub85c \ud050\uc5b4\ubc84\uc2a4\ub294 \ud6c4\ubcf4\ubb3c\uc9c8\uc744 \ubc1c\uad74\ud574 \ud30c\ub294 \uae30\uc5c5\uc774 \uc544\ub2c8\ub77c, \ud6c4\uae30 \uc784\uc0c1\uacfc \uc0c1\uc5c5\ud654\uae4c\uc9c0 \uc8fc\ub3c4\ud560 \uc218 \uc788\ub294 \uae30\uc5c5\uc744 \ubaa9\ud45c\ub85c \ud558\uace0 \uc788\ub2e4. “\uc57d\uc744 \uc5b4\ub5bb\uac8c \uc124\uacc4\ud574\uc57c \ud558\ub294\uc9c0 \uc544\ub294 \uc870\uc9c1\uc5d0\uc11c, \uc774\uc81c\ub294 \uadf8 \uc57d\uc744 \uc2dc\uc7a5\uc5d0 \uac00\uc838\uac00\ub294 \uc2e4\ud589\ub825\uc744 \uac16\ucd98 \uc870\uc9c1\uc73c\ub85c \ub098\uc544\uac00\uace0 \uc788\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n","protected":false},"featured_media":5354,"parent":0,"template":"","meta":{"_acf_changed":false},"record-category":[],"class_list":["post-5322","record","type-record","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/record\/5322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/record"}],"about":[{"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/types\/record"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/media\/5354"}],"wp:attachment":[{"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/media?parent=5322"}],"wp:term":[{"taxonomy":"record-category","embeddable":true,"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/record-category?post=5322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}