{"id":4984,"date":"2023-04-07T01:21:43","date_gmt":"2023-04-06T16:21:43","guid":{"rendered":"https:\/\/cureverse.co.kr\/en\/?post_type=record&p=4984"},"modified":"2025-05-19T01:31:06","modified_gmt":"2025-05-18T16:31:06","slug":"%eb%82%9c%ec%b9%98%ec%84%b1-%eb%87%8c%ec%a7%88%ed%99%98-%ec%8b%a0%ec%95%bd-%ed%9b%84%eb%b3%b4-%eb%ac%bc%ec%a7%88-%ea%b0%9c%eb%b0%9c-%eb%8b%a8%ec%88%a8%ec%97%90-%ec%8a%a4%ed%83%80%ed%94%8c","status":"publish","type":"record","link":"https:\/\/cureverse.co.kr\/en\/record\/%eb%82%9c%ec%b9%98%ec%84%b1-%eb%87%8c%ec%a7%88%ed%99%98-%ec%8b%a0%ec%95%bd-%ed%9b%84%eb%b3%b4-%eb%ac%bc%ec%a7%88-%ea%b0%9c%eb%b0%9c-%eb%8b%a8%ec%88%a8%ec%97%90-%ec%8a%a4%ed%83%80%ed%94%8c\/","title":{"rendered":"\ub09c\uce58\uc131 \ub1cc\uc9c8\ud658 \uc2e0\uc57d \ud6c4\ubcf4 \ubb3c\uc9c8 \uac1c\ubc1c\u2026 \ub2e8\uc228\uc5d0 \uc2a4\ud0c0\ud50c\ub808\uc774\uc5b4 \ub41c \uac15\uc18c\uae30\uc5c5"},"content":{"rendered":"

\"\"<\/p>\n

 <\/p>\n

\ub1cc \uc9c8\ud658 \uce58\ub8cc\uc81c\ub97c \uc800\ubd84\uc790 \uc57d\ubb3c\ub85c \uac1c\ubc1c\ud558\uace0 \uc788\ub294 \ud050\uc5b4\ubc84\uc2a4\ub294 \uacfc\ud559\uae30\uc220\uc815\ubcf4\ud1b5\uc2e0\ubd80\uc758 \ucc3d\uc5c5 \uc720\ub3c4\ud615 \uc5f0\uad6c\u00b7\uac1c\ubc1c(R&D) \uc0ac\uc5c5\uc778 \u2018\ubc14\uc774\uc624\uc2a4\ud0c0\uacfc\uc81c\u2019\uc640 \ud55c\uad6d\uacfc\ud559\uae30\uc220\uc5f0\uad6c\uc6d0(KIST\u00b7\uc6d0\uc7a5 \uc724\uc11d\uc9c4) \uc790\uccb4 \ucc3d\uc5c5 \uc9c0\uc6d0 \uc0ac\uc5c5\uc778 \u2018\ub514\ub524\ub3cc \uacfc\uc81c\u2019 \uae30\ubc18\uc73c\ub85c \uc9c0\ub09c 2021\ub144 10\uc6d4 \uc124\ub9bd\ub410\ub2e4. \ud050\uc5b4\ubc84\uc2a4\ub294 \uc800\ubd84\uc790 \uc2e0\uc57d \ud6c4\ubcf4 \ubb3c\uc9c8\uc744 \uc55e\uc138\uc6cc, \ub09c\uacf5\ubd88\ub77d\uc73c\ub85c \uc5ec\uaca8\uc84c\ub358 \u2018\ub1cc \uc9c8\ud658\u2019 \uad00\ub828 \uc2e0\uc57d \uac1c\ubc1c\uae4c\uc9c0 \uc608\uace0\ud558\uace0 \uc788\ub2e4.<\/p>\n

\u25c7\ud050\uc5b4\ubc84\uc2a4, \u2018\ub09c\uce58\uc131 \ub1cc \uc9c8\ud658 \uce58\ub8cc\uc81c\u2019\uc5d0 \uc8fc\ubaa9\ud558\ub2e4<\/p>\n

\uc2e0\uc57d\uc740 \ud06c\uac8c \ud56d\uccb4\ub97c \ud3ec\ud568\ud558\ub294 \u2018\ub2e8\ubc31\uc9c8 \uc2e0\uc57d\u2019\uacfc \u2018\uc800\ubd84\uc790 \uc2e0\uc57d\u2019\uc73c\ub85c \ub098\ub25c\ub2e4. \uc774\uc911 \uc800\ubd84\uc790 \ud654\ud569\ubb3c \uc2e0\uc57d\uc740 \ud2b9\ud788 \ub1cc \uc9c8\ud658 \uce58\ub8cc\uc81c \uac1c\ubc1c\uc5d0 \uc788\uc5b4\uc11c \uc5ec\ub7ec \uc7a5\uc810\uc744 \uac00\uc9c4 \ubd84\uc57c\ub77c \ud560 \uc218 \uc788\uaca0\ub2e4. \ucd5c\uadfc\uae4c\uc9c0\ub3c4 \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA)\uc774 \uc2b9\uc778\ud55c \uc2e0\uc57d \uac00\uc6b4\ub370 \uc0c1\ub2f9\uc218\ub97c \uc800\ubd84\uc790 \uc2e0\uc57d\uc774 \ucc28\uc9c0\ud560 \uc815\ub3c4\ub2e4.<\/p>\n

\ud050\uc5b4\ubc84\uc2a4\ub294 \uae00\ub85c\ubc8c \uc218\uc900\uc758 \uc800\ubd84\uc790 \ubc1c\uad74 \uae30\uc220\ub825\uc744 \ubcf4\uc720\ud558\uace0 \uc788\ub2e4. \uc774 \ud68c\uc0ac\ub294 \uc54c\uce20\ud558\uc774\uba38\ubcd1(\uce58\ub9e4)\uc774\ub098 \ud30c\ud0a8\uc2a8\ubcd1\ucc98\ub7fc \uadfc\ubcf8\uc801 \uce58\ub8cc\uc81c\uac00 \uc5c6\uac70\ub098, \ub2e4\ubc1c\uc131 \uacbd\ud654\uc99d\ucc98\ub7fc \uc548\uc804\ud55c \uce58\ub8cc\uc81c\uac00 \uc5c6\ub294 \ub09c\uce58\uc131 \ub1cc \uc9c8\ud658\uc5d0 \uc8fc\ubaa9\ud588\ub2e4. \ub09c\uce58\uc131 \ub1cc \uc9c8\ud658 \uce58\ub8cc\uc81c\ub294 \ubbf8\ucda9\uc871 \uc218\uc694\uac00 \ucc9c\ubb38\ud559\uc801\uc778 \uc720\ub9dd \ubd84\uc57c\uc774\ub2e4. \uc2e0\uc57d\uc774 \uac1c\ubc1c\ub418\uba74 \ud30c\uae09\ub825\uc774 \uc5c4\uccad\ub0a0 \uac83\uc73c\ub85c \uae30\ub300\ub97c \ubaa8\uc73c\uace0 \uc788\ub2e4.<\/p>\n

\uc2e0\uc57d \uac1c\ubc1c\uc740 \u2018\ud30c\uc774\ud504\ub77c\uc778(\uc5f0\uad6c \uac1c\ubc1c \uc911\uc778 \ud504\ub85c\uc81d\ud2b8)\u2019\uc774 \ud575\uc2ec\uc774\ub2e4. \uc88b\uc740 \uc2e0\uaddc \ud30c\uc774\ud504\ub77c\uc778 \ud655\ubcf4 \uc5ec\ubd80\uac00 \uc2e0\uc57d \uac1c\ubc1c \uc2a4\ud0c0\ud2b8\uc5c5\uc758 \uc9c0\uc18d \uac00\ub2a5\uc131\uacfc \uc131\ud328\ub97c \uc88c\uc6b0\ud55c\ub2e4.<\/p>\n

\ud050\uc5b4\ubc84\uc2a4\ub294 \uc774\ub97c \uc774\uc0c1\uc801\uc73c\ub85c \ucda9\uc871\ud558\ub294 \uae30\uc220 \ud3ec\ud2b8\ud3f4\ub9ac\uc624\ub97c \uad6c\ucd95\ud558\uace0 \uc788\ub2e4. \uccab\uc9f8\uac00 \ud604\uc7ac \ubcf4\uc720\ud558\uace0 \uc788\ub294 \uc2e0\uc57d \ud30c\uc774\ud504\ub77c\uc778\ub4e4\uc774\uace0, \ub458\uc9f8\uac00 \uc774\ub7ec\ud55c \ud6c4\ubcf4 \uc57d\ubb3c\uc744 \uac80\uc99d\u00b7\ubc1c\uad74\ud560 \uc218 \uc788\ub294 \ud50c\ub7ab\ud3fc \ubc0f \uc5ed\ub7c9\uc774\ub2e4.<\/p>\n

\u25c7\ud050\uc5b4\ubc84\uc2a4\uc758 \ud575\uc2ec \ud30c\uc774\ud504\ub77c\uc778 \ub450 \uac00\uc9c0 \u2018CV-01\u2032\uacfc \u2018CV-02\u2032\ub294?<\/p>\n

\ud050\uc5b4\ubc84\uc2a4\ub294 \uc9c0\ub09c\ud574 \ub450 \uac1c\uc758 \uc8fc\uc694 \ube44\uc784\uc0c1 \ud30c\uc774\ud504\ub77c\uc778\uc744 \uac1c\ubc1c\ud558\uba70 \uc774\uc288\uc758 \uc911\uc2ec\uc5d0 \uc130\ub2e4. \uc54c\uce20\ud558\uc774\uba38\ubcd1(\uce58\ub9e4) \uce58\ub8cc\uc81c \ud6c4\ubcf4 \ubb3c\uc9c8 \u2018CV-01\u2032\uacfc \uc790\uac00\uba74\uc5ed\uc9c8\ud658\uc778 \ub2e4\ubc1c\uc131 \uacbd\ud654\uc99d \uce58\ub8cc\uc81c \ud6c4\ubcf4\ubb3c\uc9c8 \u2018CV-02\u2032\ub2e4.<\/p>\n

\uccab \ubc88\uc9f8 \ud30c\uc774\ud504\ub77c\uc778 \uc784\uc0c1 \ud6c4\ubcf4\uc778 \u2018CV-01\u2032\uc740 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc774\ub098 \ud30c\ud0a8\uc2a8\ubcd1\uacfc \uac19\uc740 \ub1cc \uc9c8\ud658 \uce58\ub8cc\ub97c \uc704\ud55c \uac83\uc774\ub2e4. \ud6a8\uacfc\uac00 \uc99d\uc0c1 \uc644\ud654 \uc218\uc900\uc778 \uae30\uc874 \uc57d\uacfc \ub2ec\ub9ac, \uadfc\uc6d0\uc801 \uce58\ub8cc\uc81c \ud6c4\ubcf4 \ubb3c\uc9c8\uc774\ub2e4. \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc5d0 \uac78\ub9b0 \uc950\ub85c \ub3d9\ubb3c \uc2e4\ud5d8(In Vivo)\uc744 \uc5ec\ub7ec \ucc28\ub840 \ubc18\ubcf5\ud55c \uacb0\uacfc, CV-01\uc774 \uc801\uc6a9\ub41c \uce58\ub9e4 \uc950 \ubaa8\ub378\uc774 \uc815\uc0c1 \uc950\uc640 \uc720\uc0ac\ud55c \ud559\uc2b5\u00b7\uae30\uc5b5 \ub2a5\ub825\uc744 \ubcf4\uc600\ub2e4. \uc54c\uce20\ud558\uc774\uba38\ubcd1\uacfc \ud30c\ud0a8\uc2a8\ubcd1\uc5d0\uc11c \ubaa8\ub450 \uc720\uc758\ubbf8\ud55c \uac1c\uc120 \ud6a8\ub2a5 \uacb0\uacfc\uac00 \ub098\uc654\ub2e4.<\/p>\n

CV-01\uc740 \ub9e4\uc6b0 \uc120\ud0dd\uc801\uc73c\ub85c \uc57d\ubb3c \ud0c0\uae43\uc778 \u2018Keap1\u2032\uc744 \ubcc0\ud615\uc2dc\ud0a4\ub294 \u2018\ud601\uc2e0 \uc2e0\uc57d(First in Class)\u2019\uc73c\ub85c \uc815\uc758\ud560 \uc218 \uc788\ub2e4. Keap1\uacfc Nrf2\ub294 \ub1cc \uc5fc\uc99d \uc9c8\ud658\uc5d0 \uc911\uc694\ud55c \ud0c0\uae43\uc774 \ub418\ub294 \ub2e8\ubc31\uc9c8\uc774\ub2e4. \uc774\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \ubcc0\ud615\uc2dc\ucf1c \uc138\uacc4 \ucd5c\ucd08\ub85c \uce58\ub9e4 \uce58\ub8cc\uc81c \uac1c\ubc1c\uc5d0 \ub098\uc11c\uace0 \uc788\ub2e4.<\/p>\n

\uc57d \ud2b9\uc131 \ubc1c\ud718\uc5d0 \ud544\uc694\ud55c \uc885\ud569\uc801 \uc131\uc9c8\uc778 \u2018\uc57d\ubb3c\uc131\u2019\uc774 \ub6f0\uc5b4\ub098\ub2e4. \ud761\uc218\u00b7\ubd84\ud3ec\u00b7\ub300\uc0ac\u00b7\ubc30\ucd9c\uc774 \uc798 \uc774\ub904\uc9c0\uba70 \ub3c5\uc131\ub3c4 \uc5c6\ub2e4\ub294 \uac83\uc774\ub2e4. CV-01\uc740 \uc774\ub97c \ub2e4\ub8e8\ub294 \u2018ADME\/Tox\u2019 \ud3c9\uac00\uc5d0\uc11c \ub1cc \uc9c8\ud658 \uce58\ub8cc\uc81c\ub85c \uc801\uc6a9\ud560 \uc218 \uc788\ub294 \uc218\uc900\uc758, \ub9e4\uc6b0 \uc6b0\uc218\ud55c \uc57d\ubb3c\uc131 \ud504\ub85c\ud30c\uc77c\uc744 \ubcf4\uc600\ub2e4. \uc9c0\ub09c 3\uc6d4 \ub9d0\uc5d0\ub294 CV-01 \ud30c\uc774\ud504\ub77c\uc778\uc774 \uce58\ub9e4\uadf9\ubcf5\uc5f0\uad6c\uac1c\ubc1c\uc0ac\uc5c5\ub2e8\uc758 \ube44\uc784\uc0c1 \ub2e8\uacc4 \uacfc\uc81c\uc5d0 (\uc608\ube44)\uc120\uc815\ub418\uba70 \uc815\ubd80\ub85c\ubd80\ud130 \uadf8 \uac00\uce58\ub97c \uc778\uc815\ubc1b\uc558\ub2e4. \ub610\ud55c \ube44\uc784\uc0c1 \uc2dc\ud5d8 \ub4f1\uc744 \uc704\ud55c 15\uc5b55000\ub9cc\uc6d0\uc758 \uc5f0\uad6c\ube44 \uc9c0\uc6d0\uc73c\ub85c \uc784\uc0c1 \uac1c\ubc1c\uc5d0 \ud0c4\ub825\uc744 \ubc1b\uc558\ub2e4.<\/p>\n

\ub450 \ubc88\uc9f8 \ud30c\uc774\ud504\ub77c\uc778 \u2018CV-02\u2032\ub294 \uc790\uac00\uba74\uc5ed\uc9c8\ud658\uc778 \ub2e4\ubc1c\uc131 \uacbd\ud654\uc99d \uce58\ub8cc\uc81c \ud6c4\ubcf4 \ubb3c\uc9c8\uc774\ub2e4. \uae30\uc874 \uce58\ub8cc\uc81c\uc640 \ub9c8\ucc2c\uac00\uc9c0\ub85c \ud608\uc561 \ub0b4 \uba74\uc5ed\uc138\ud3ec \uc774\ub3d9\uc744 \uc870\uc808\ud558\ub294 \u2018S1P1\u2032 \ub2e8\ubc31\uc9c8\uc774 \uce58\ub8cc \ud0c0\uae43\uc774\ub2e4. \uc2ec\uc7a5\uacfc \uac04 \ub4f1 \ub2e4\ub978 \uc7a5\uae30\uc5d0 \ubbf8\uce58\ub294 \ubd80\uc791\uc6a9\uc744 \ud574\uacb0\ud588\ub2e4\ub294 \uc810\uc774 \ucc28\ubcc4\ud654\ub410\ub2e4.<\/p>\n

\ub2e4\ubc1c\uc131 \uacbd\ud654\uc99d\uc740 \ud1f4\ud589\uc131 \uc9c8\ud658 \uce58\ub8cc\uc81c \uc2dc\uc7a5\uc5d0\uc11c \ud070 \ube44\uc911\uc744 \ucc28\uc9c0\ud55c\ub2e4. \ud050\uc5b4\ubc84\uc2a4 \uce21\uc740 \u201c\uc0ac\ub78c \uc2ec\uc7a5 \uc870\uc9c1\uc744 \uc774\uc6a9\ud55c \uc2ec\uc7a5\uacc4 \ubd80\uc791\uc6a9 \uadf9\ubcf5 \uc2dc\ud5d8 \uacb0\uacfc, \ub2e4\uad6d\uc801 \ud68c\uc0ac\uc758 \uacbd\uc7c1 \uc57d\ubb3c \ub300\ube44 \ubd80\uc791\uc6a9\uc774 100\ubd84\uc758 1 \uc218\uc900\uc784\uc744 \ud655\uc778\ud588\ub2e4\u201d\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

\u25c7\ucc3d\uc5c5 1\ub144 \ub9cc\uc5d0 85\uc5b5\uc6d0 \uaddc\ubaa8 \uc2dc\ub9ac\uc988 A \ud22c\uc790 \uc720\uce58\u2026\u201d\uc720\ub2c8\ucf58 \uae30\uc5c5 \ub418\uaca0\ub2e4\u201d<\/p>\n

\ud050\uc5b4\ubc84\uc2a4\ub294 \ud575\uc2ec \ud30c\uc774\ud504\ub77c\uc778 CV-01\uacfc CV-02\uc758 \ube44\uc784\uc0c1 \uc2e4\ud5d8\uc744 \uc62c\ud574 \uc911 \uc644\ub8cc\ud558\uace0 \ub0b4\ub144 \ucd08\uc5d0 \uc784\uc0c1 1\uc0c1 IND(\uc784\uc0c1\uc2dc\ud5d8\uacc4\ud68d)\ub97c \uc2e0\uccad\ud560 \uacc4\ud68d\uc774\ub2e4.<\/p>\n

\ucc3d\uc5c5 1\ub144 \ub9cc\uc5d0 85\uc5b5\uc6d0 \uaddc\ubaa8\uc758 \uc2dc\ub9ac\uc988 A \ud22c\uc790\ub97c \ub04c\uc5b4\ub0b8 \ud050\uc5b4\ubc84\uc2a4\ub294 \u20182022 \uc5f0\uad6c\uac1c\ubc1c\ud2b9\uad6c \ud601\uc2e0\uae30\uc5c5 \ud1b5\ud569 IR \uacbd\uc9c4\ub300\ud68c\u2019\uc5d0\uc11c \uae30\uc220\ub300\uc0c1(\uacfc\ud559\uae30\uc220\uc815\ubcf4\ud1b5\uc2e0\ubd80 \uc7a5\uad00\uc0c1)\ub3c4 \ubc1b\uc558\ub2e4.<\/p>\n

\ud050\uc5b4\ubc84\uc2a4\uc758 \uc131\uc7a5 \uac00\ub2a5\uc131\uc744 \ubb3b\uc790 \uc870\uc131\uc9c4 \ub300\ud45c\ub294 \u201c20\uc5ec \ub144\uac04 \uc218\ud589\ud588\ub358 \uc800\ubd84\uc790 \uc2e0\uc57d \uac1c\ubc1c \uacbd\ud5d8\uc73c\ub85c \ucc9c\ubb38\ud559\uc801 \uc2dc\uc7a5\uc744 \ub3c5\uc810\ud560 \uc218 \uc788\ub294 \uc870(\u5146) \ub2e8\uc704 \uac00\uce58\uc758 \uc720\ub2c8\ucf58 \uae30\uc5c5\uc73c\ub85c \uc131\uc7a5\ud558\uaca0\ub2e4\u201d\uace0 \ud798\uc8fc\uc5b4 \ub9d0\ud588\ub2e4.<\/p>\n","protected":false},"featured_media":4985,"parent":0,"template":"","meta":{"_acf_changed":false},"record-category":[],"class_list":["post-4984","record","type-record","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/record\/4984","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/record"}],"about":[{"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/types\/record"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/media\/4985"}],"wp:attachment":[{"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/media?parent=4984"}],"wp:term":[{"taxonomy":"record-category","embeddable":true,"href":"https:\/\/cureverse.co.kr\/en\/wp-json\/wp\/v2\/record-category?post=4984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}